Leerink’s Geoffrey Porges and Assaf Vestin are attending the annual American Society of Clinical Oncology, or ASCO, meeting and came away seeing the “biggest positive impact” forCelgene (CELG), but only a “modest” impact for Amgen (AMGN),Regeneron Pharmaceuticals (REGN) and Gilead Sciences (GILD). They explain:
We see the biggest impact for Celgenes lenalidomide (Revlimid) in multiple myeloma (MM) following data from the Phase 3 CASTOR and a meta-analysis of lenalidomide maintenance following ASCT in newly diagnosed MM. Other notable data disclosures came from Regeneron and its anti-PD-1 antibody, REGN2810, Gileads MMP9 inhibitor GS-5745in gastric cancer, and Amgens oncolytic virus, T-Vec in combination with pembrolizumab in unresectable melanoma.
Celgene (MP) Revlimid Reinforces Core Position in Myeloma. Two abstracts presented at ASCO reinforce lenalidomides positioning in two different multiple myeloma settings. The first was a meta-analysis of lenalidomide maintenance therapy following autologous stem cell transplant (ASCT) in newly diagnosed multiple myeloma (NDMM) patients. The analysis, which was based on three randomized studies, showed that lenalidomide maintenance provided a survival benefit over placebo (HR=0.74, p=0.001). Prior exposure to lenalidomide in induction therapy was correlated with improved survival benefit. This analysis supports the use of lenalidomide in the subset of patients treated with ASCT (25-30%)…
Top 5 Quality Companies For 2016: Navidea Biopharmaceuticals, Inc.(NAVB)
Navidea Biopharmaceuticals, Inc., a biopharmaceutical company, focuses on the development and commercialization of precision immunodiagnostic agents and immunotherapeutics. The company offers Lymphoseek, a receptor-targeted small-molecule radiopharmaceutical used in the evaluation of lymphatic basins that may have cancer involvement in patients; and Manocept platform to target the CD206 mannose receptor expressed on activated macrophages. Its neurological development programs include NAV4694, an Fluorine-18 labeled positron emission tomography imaging agent, which is used as an aid the imaging and evaluation of patients with signs or symptoms of Alzheimers disease and mild cognitive impairment; and NAV5001, an Iodine-123 labeled single photon emission computed tomography imaging agent that is used as an aid in the diagnosis of Parkinsons disease and other movement disorders with potential use as a diagnostic aid in dementi a. Navidea Biopharmaceuticals, Inc. has research and development agreements with University of California. The company was formerly known as Neoprobe Corporation and changed its name to Navidea Biopharmaceuticals, Inc. in January 2012. Navidea Biopharmaceuticals, Inc. was founded in 1983 and is headquartered in Dublin, Ohio.
- [By Monica Gerson]
Navidea Biopharmaceuticals Inc (NYSE: NAVB) shares rose 8.80 percent to $0.950 in pre-market trading as the company reported an unsolicited offer to refinance CRG loan.
Top 5 Quality Companies For 2016: KeyCorp(KEY)
KeyCorp, incorporated on December 31, 1958, is a bank holding company. The Bank operates through its subsidiary, KeyBank National Association (KeyBank), which is engaged in providing banking services. Through KeyBank and other subsidiaries, the Company provides a range of retail and commercial banking, commercial leasing, investment management, consumer finance, commercial mortgage servicing and special servicing, and investment banking products and services to individual, corporate and institutional clients. The Company’s segments include Key Community Bank and Key Corporate Bank. Its Other Segments consist of corporate treasury, principal investing unit and various exit portfolios.
The Company provides its services across the country through KeyBank’s approximately 970 full-service retail banking branches and a network of over 1,260 automated teller machines (ATMs) in approximately 10 states, as well as additional offices, online and mobile banking capabilit ies, and a telephone banking call center. In addition to the customary banking services of accepting deposits and making loans, the Company offers personal, securities lending and custody services, personal financial services, access to mutual funds, treasury services, investment banking and capital markets products, and international banking services. The Company provides investment management services to clients that include large corporate and public retirement plans, foundations and endowments, high-net-worth individuals and multi-employer trust funds established for providing pension or other benefits to employees. The Company provides other financial services both within and outside of its banking markets through various nonbank subsidiaries. These services include community development financing, securities underwriting and brokerage. It also provides merchant services to businesses directly and through an equity participation in a joint venture.
Key Comm unity Bank
Key Community Bank serves individual! s and small to mid-sized businesses by offering a range of deposit, investment, lending, credit card, and personalized wealth management products and business advisory services. These products and services are provided through the Company’s relationship managers and specialists working in its branch network, which is organized into various geographic regions, including Pacific, Rocky Mountains, Indiana, Western Ohio and Michigan, Eastern Ohio, Western New York, Eastern New York and New England.
Key Community Bank provides branch-based deposit and investment products, personal finance services, and loans, including residential mortgages, home equity, credit card, and various types of installment loans. In addition, financial, estate and retirement planning, asset management services, and Delaware Trust capabilities are offered to assist high-net-worth clients with their banking, trust, portfolio management, insurance, charitable giving and related needs. It provi des small businesses with deposit, investment and credit products, and business advisory services. Mid-sized businesses are provided products and services that include commercial lending, cash management, equipment leasing, investment and employee benefit programs, succession planning, access to capital markets, derivatives, and foreign exchange.
Key Corporate Bank
Key Corporate Bank is a full-service corporate and investment bank focused on serving the needs of middle market clients in industry sectors, which include consumer, energy, healthcare, industrial, public sector, real estate and technology. Key Corporate Bank delivers a product suite of banking and capital markets products to its clients, including syndicated finance, debt and equity capital markets, commercial payments, equipment finance, commercial mortgage banking, derivatives, foreign exchange, financial advisory and public finance. Key Corporate Bank is also a servicer of commercial mortgage loans and a special servicer of commercial mortgage! -backed s! ecurities (CMBS). Key Corporate Bank delivers its product capabilities to clients of Key Community Bank.
- [By Ben Levisohn]
For Investors With More Constructive Outlook On Rates and Economy, We
Believe Bank of America (BAC) Is Better Play The risk of downgradingJPMorgan here is that we continue to see good news on the rate front, but we preferBank of America since we view it as better positioned for higher rates and more room for multiple revaluation (Bank of America currently trades at highest implied cost of equity in our group of 11.8% vsJPMorgan at 10.5%).Bank of America does carry similar regulatory risk as JPMorgan (such as higher GSIB buffers), so for investors looking for a rate play with less regulatory risk we like Citizens Financial Group (CFG). We also view KeyCorp (KEY) as best value in the group with the most room for multiple expansion (currently 11.0% cost of equity).
- [By Ben Levisohn]
Lee offers 22 stocks that could benefit from the correlation trade: Western Digital (WDC), Xerox (XRX), First Solar, Ford Motor, Best Buy (BBY), PulteGroup (PHM), AutoNation (AN), Textron (TXT), Jacobs Engineering Group (JEC), Mosaic, BB&T (BBT), Fifth Third Bancorp (FITB),Loews (L), Regions Financial (RF), KeyCorp (KEY), Comerica (CMA), Leucadia National (LUK), Zions Bancorp (ZION), Valero Energy (VLO), Marathon Oil, Cardinal Health (CAH), and Pepco Holdings (POM).
- [By Ben Levisohn]
The twenty stocks in Worth’s basket are: Ameriprise Financial (AMP) Bank of America, Banner (BANR), Citigroup, Citizens Financial Group (CFG), East West Bancorp (EWBC), First NBC Bank Holding (FNBC), HFF (HF), KeyCorp(KEY), Legacy Texas Financial Group (LTXB), Lincoln National (LNC), Morgan Stanley, Old National Bancorp (ONB), PacWest Bancorp (PACW), PNC Financial Services Group (PNC), Principal Financial Group (PFG), Stifel Financial (SF), SVB Financial Group (SIVB), TCF Financial (TCB), and Wells Fargo.
Top 10 Insurance Companies To Invest In 2016: Yandex N.V.(YNDX)
Yandex N.V. (Yandex), incorporated on June 1, 2004, is an Internet and technology company, and operates an Internet search engine. The Company’ s segments include Search and Portal, offers a range of services in Russia, Ukraine, Belarus and Kazakhstan, among which are search, location-based, personalized and mobile services, that enable the Company’s users to find relevant and objective information to communicate and connect over the Internet, from both their desktops and mobile devices; E-commerce, which includes Yandex.Market e-commerce gateway service that gives retailers an additional platform to reach customers seeking specific retailer, product or price information; Classifieds, which includes online advertising and listing services, and Taxi, which offers online transportation service delivered through Yandex and Taxi operates in approximately 10 cities across Russia and in Minsk, Belarus. The Company also operates Experimental businesses, which includes media servi ces (including KinoPoisk, Yandex.Music, Yandex.Radio, Yandex.Tickets and Yandex.Afisha), Yandex Data Factory, discovery services (including Yandex Zen and Yandex Launcher), and search and portal in Turkey.
The Company offers a range of applications for mobile devices running iPhone operating system (iOS), Android and Windows Phone operating systems. The applications include Yandex.Navigator, Yandex.Maps, Yandex Browser and Yandex.Search. Other applications include Yandex.Metro, Yandex.Transport, KinoPoisk, Yandex.Mail, Yandex.Weather, Yandex.Market, Auto.ru, Yandex.Disk, Yandex.Music, Yandex.Timetables, Yandex.Translate and Yandex.Taxi. Its services and applications are also distributed by a limited number of original equipment manufacturers (OEMs), retailers, browser makers and telecom operators in Russia. The Company offers advertisers both text-based advertising and display advertising. Text-based advertisements are targeted to the particular user query on it s search engine result pages, and on search result pages of ! its partners, as well as to the content of a particular Website or Webpage being viewed, or to user behavior or characteristics. Display advertisements consist of graphical and programmatic advertisements that appear on specific pages.
Yandex.Direct is the Company’s auction-based advertising placement service. Yandex.Direct lets advertisers deliver text-based advertisements targeted at particular search queries or content on Yandex Websites or third-party Websites in the Yandex Advertising Network. Yandex.Direct features an automated, online sign-up process that enables advertisers to create and launch their advertising campaigns. Its Web analytics tool, Yandex.Metrica, is a Web analytics system in Russia.
Search and Portal
The Yandex Search engine offers access to a range of information available online. The Company utilizes linguistics, mathematics and statistical analysis to develop algorithms that extract, compile, systematize and p resent relevant information to users. Its organic search results are ranked by computer algorithms based on relevance and it segregates organic results from paid results to avoid confusing its users. The anti-spam protection detects and downgrades pages with low informational content, made-for-advertising and doorway sites, pages with pop-under banners, content farms and scraped-content pages. The Company supplements the results from its Web index with results from its parallel search system, which blends listings from all available Yandex specialized and vertical searches according to their relative relevance, such as Yandex.Images and Yandex.Video, Yandex.News and Yandex.Maps, among others.
The Company offers personalized search that provides search suggestions, as well as search results that are aligned with individual interests of its users. Its news aggregation and information service, the online news aggregation service in Russia, provides a media overview for its users. It aggregates and presents local, national a! nd intern! ational news from approximately 6,700 news sources across the world. Yandex.Maps provide detailed maps of over 1,100 cities and towns in Russia and approximately 20 cities in Ukraine, Kazakhstan and Belarus, as well as a detailed map of Turkey and satellite images of the whole world. In addition to graphical maps, it offers satellite images and hybrid maps (an amalgamation of satellite images and graphic maps), panoramic views, public transportation routes and driving directions in browsers and mobile device applications. Yandex.Maps is also available through application programming interfaces (APIs), which allow Web developers to embed and use interactive maps in third-party Websites, as well as to add extra layers of information.
The Company offers Yandex.Navigator, a mobile application, which provides turn-by-turn navigation. It incorporates a voice input function and a set of voice commands that allow users to interact with the application without touching t he screen. The Yandex.Transport mobile application provides users with real-time data on public transport in various Russian cities. The Yandex.Parking mobile application allows drivers to find available spots in partner parking spaces and pay for them right from the application. Its Geo-Direct Business Directory service enables advertisers to pay for premium placement.
The Yandex.Mail provides users with an access to their e-mail accounts. Its features include threaded and unthreaded views; direct access to Yandex.Disk, Yandex.Money and other Yandex services; auto-tagging, which automatically recognizes and tags certain types of e-mails; smart preview, which allows its users to see the first line of any e-mail in their inbox without having to open it, and Address Book, which recognizes both Latin and Cyrillic transliterations of names, and aggregates all e-mails from the same sender regardless of the language used. Yandex.Mail also features an unsubscribe butto n allowing users to opt out from mailing lists in a single c! lick. Its! Yandex.Mail application is available to Android and iOS users. It allows users to work with multiple e-mail accounts, filter and sort e-mails using Marker, its machine-learning technology that can recognize an e-mail type, and compose e-mails offline, and offers a range of other features. Its mobile push-email technology allows for the instantaneous delivery of new e-mails to mobile inboxes. Its Yandex.Disk service is a cloud-based storage service that allows users to upload, store, read and share files in various formats and sizes. Users can store photos, videos or documents online so that they can be accessed devices, such as personal computer (PC), laptop, tablet or smartphone. The Yandex.Disk mobile application is available for iOS, Android-based and Windows Phone smartphones.
The Company’s Yandex.Weather service allows its users to monitor weather conditions across the globe. The Company offers hyperlocal weather information based on its weather forecastin g technology, Meteum. It gives forecasts for areas as local as specific parts of a city or even individual buildings. Yandex.Weather calculates a new forecast every time a user consults the service. It determines a person’s position down to their current geographic coordinates and shows a fresh forecast. The new Yandex.Weather service offers hyperlocal weather forecasts for people living in approximately 40 regions of Russia and is available on desktop, as well as through applications for iOS and Android.
The Company’s homepage provides a gateway to the means of information available online. Users can find answers to their explicit questions through its search box, as well as to their implicit questions through current news, weather and road traffic reports, television and movie schedules, and other services, presented on its home page. The Company also offers localized homepages for specific geographic markets. Its Yandex Browser allows surfing over the Interne t. After typing a search in the browser’s smartbox, the user! can see ! a snippet about what they are searching for a thing, a product, a person or an event. The Company’s browser also provides its language translation capabilities; able to resume interrupted file downloads; has an automatically generated tableau menu; synchronization of bookmarks and history between desktop and mobile versions, and quick call capability, among other things. It offers mobile versions of Yandex Browser for iOS and Android smartphones and tablets.
The Company’s Yandex.Market e-commerce gateway service gives retailers an additional platform to reach customers seeking specific retailer, product or price information. Product search on Yandex.Market is designed to deliver relevant shopping results to its users. Retailers submit their product catalogs and price lists to the Company in a structured online format, enabling it to provide detailed information in response to relevant user queries, either through its search engine or its Yandex.Market service. Yandex.Market, incorporates its recommendation technology, which is used across other Yandex products and provides users with personal product recommendations. Yandex.Market provides product information, price comparisons and consumer generated reviews of products and online retailers. It features approximately 90 million offerings in over 2,000 product categories from approximately 19,000 participating retailers.
Yandex.Delivery aggregates a range of third-party delivery carriers, courier services, pick-up points and automated self-service kiosks to accommodate delivery of goods across Russia. Its retailer customers can utilize software to display delivery options, including price and time of delivery on their Website.
Yandex’s Classifieds business unit includes Auto.ru, Yandex.Auto, Yandex.Realty, Yandex.Jobs and Yandex.Travel. Auto.ru is the automobile-related Russian Website with approximately 20 m illion monthly visitors and over 60 million monthly visits. ! Auto.ru a! llows users, both private individuals, as well as auto dealers, to post listings of automobiles, motorcycles and commercial vehicles. Auto.ru offers a range of filters that allows potential buyers to find the exact item they are looking for. Auto.ru is also available on mobile through the mobile Web and as applications in iOS and Android. Yandex.Realty is its real estate classifieds service, acting as both an aggregator of advertisements from other Websites and a place where private individuals and realtors can place their listings directly. The service provides listings for both sale and rental of apartments, rooms, houses and vacation homes. Yandex.Realty is also available as an application for iOS and Android.
Yandex.Jobs is a service for job seekers that is available as a mobile application for Android and iOS. Yandex.Travel allows users to search for a vacation using multiple criteria. It provides information, such as hotel reviews that it generates using i ts fact extraction technology.
Yandex.Taxi is a transportation service. It offers services in Moscow, Saint Petersburg, and other cities. The Company operates its service in approximately 10 cities across Russia, including Yekaterinburg, Perm, Novosibirsk, Samara, Sochi and many others.
The Company’s Media services unit consists of a range of services that provide its users with streaming audio and video, entertainment and hyperlocal weather data. It includes KinoPoisk.ru, Yandex.Music, Yandex.Radio, and Yandex.Afisha and Yandex.Tickets. KinoPoisk.ru. is a Russian language Website dedicated to movies, television programs and celebrities. The service allows users to read user-generated film reviews, discover the most popular movies, watch trailers, get movie news and personalized recommendations, as well as show times and tickets. Its new version of KinoPoisk is focused on the online cinema concept, aggregat ing licensed video content from various Russian online cinem! as. Yande! x.Music is its music streaming service, which is offered as both a Web service and an application for over three mobile platforms. It offers millions of tracks from both global publishers and indie groups. Its tool helps users navigate a range of songs and albums, as well as to discover new music. The Web version is accessible free of charge, while the mobile application offers music streaming and various additional functions, including music downloads, for a monthly fee after a trial period.
Yandex.Radio is a media player service, which allows users to listen to music that suits their tastes and current activity. It shares the latter’s catalog of approximately 20 million tracks. Yandex.Afisha (playbill) allows user to select entertainment from a range of options. The service provides its users an opportunity to buy tickets to cinemas, theaters and concerts online. It incorporates personalized recommendations and operates in over 40 cities across Russia.
The Company competes with Google, Mail.ru, Microsoft, Yahoo!, Begun, Facebook, Twitter, Odnoklassniki, My World services, Gett, Uber, Aliexpress, Avito, CIAN and Drom.ru.
- [By Monica Gerson]
Benzinga's newsdesk monitors options activity to notice unusual patterns. These large volume (and often out of the money) trades were initially published intraday in Benzinga Professional . These trades were placed during Monday’s regular session.
Pier 1 Imports Inc (NYSE: PIR) Dec16 5.0 Puts Sweep: 1191 @ ASK $0.80: 1354 traded vs 102 OI: $5.32 Ref Alcoa Inc (NYSE: AA) Jul16 9.5 Puts Sweep: 1494 @ ASK $0.13: 14k traded vs 6682 OI: $10.09 Ref Sarepta Therapeutics Inc (NASDAQ: SRPT) Jul16 10.0 Puts: 3536 @ ASK $0.50: 5506 traded vs 54k OI: Earnings 8/4 $22.50 Ref Tableau Software Inc (NYSE: DATA) Jul16 47.5 Puts Sweep: 837 @ ASK $0.30: 995 traded vs 37 OI: Earnings 8/3 $50.60 Ref Yandex NV (NASDAQ: YNDX) Aug16 18.0 Puts Sweep: 532 @ ASK $0.30: 2143 traded vs 78 OI: Earnings 7/28 Before Open $22.02 Ref Wolverine World Wide, Inc. (NYSE: WWW) Aug16 22.5 Puts: 719 @ ASK $1.35: 1032 traded vs 0 OI: Earnings 7/19 $22.22 Ref Conn's Inc (NASDAQ: CONN) Jan17 5.0 Puts Sweep: 605 @ ASK $0.85: 1355 traded vs 3132 OI: $7.16 Ref
Posted-In: Huge Put PurchasesNews Options Markets
Top 5 Quality Companies For 2016: Protective Life Corporation(PL)
Protective Life Corporation and its subsidiaries engage in the production, distribution, and administration of insurance and investment products in the United States. Its Life Marketing segment markets universal life, variable universal life, level premium term insurance, and bank-owned life insurance products primarily through a network of independent insurance agents and brokers, stockbrokers, and independent marketing organizations. The company?s Acquisitions segment focuses on acquiring, converting, and servicing life insurance policies and annuity products sold to individuals, which are acquired from other companies. Its Annuities segment markets variable annuity products that offer the policyholder the opportunity to invest in various investment accounts; and fixed annuity products, such as modified guaranteed annuities, single premium deferred annuities, single premium immediate annuities, and equity indexed annuities primarily through broker-dealers, financial ins titutions, and independent agents and brokers. The company?s Stable Value Products segment offers guaranteed funding agreements to special purpose entities; fixed and floating rate funding agreements directly to the trustees of municipal bond proceeds, institutional investors, bank trust departments, and money market funds; and guaranteed investment contracts to qualified retirement savings plans. Its Asset Protection segment primarily markets extended service contracts, and credit life and disability insurance to protect consumers? investments in automobiles, watercraft, and recreational vehicles; and markets a guaranteed asset protection product primarily through a national network of approximately 3,750 automobile, marine, and recreational vehicle dealers. The company was founded in 1907 and is headquartered in Birmingham, Alabama.
- [By David Sterman]
My favorite insurers: AIG (NYSE: AIG) (which I discussed a few months ago), Protective Life (NYSE: PL) and Reinsurance Group of America (NYSE: RGA).
Top 5 Quality Companies For 2016: BioAmber Inc.(BIOA)
BioAmber Inc., an industrial biotechnology company, produces and sells bio-succinic acid to various chemical market customers in the United States. Its proprietary technology platform combines industrial biotechnology and chemical catalysis to convert renewable feedstocks into chemicals that are replacements for petroleum-derived chemicals. The companys bio-succinic acid is used in various applications, including plasticizers, polyurethanes, personal care products, resins and coatings, de-icing and coolant solutions, fine chemicals, lubricants, and food additives, as well as anti-freeze solutions, coolants solvents, water treatment chemicals, laundry tablets and bath salts, artificial leather products, and foams made with recycled polyethylene terephthalate. Its product pipeline also includes bio-succinic acid derivatives, such as 1, 4 butanediol, gamma-butyrolactone, and succinic acid based polyesters; and C6 building block chemicals comprising adipic acid, caprolactam, and hexamethylenediamine. The company sells its products directly to its customers and commercial partners, as well as indirectly through distributor in the Asia-Pacific region. It has strategic relationships with various companies, including PTTMCC Biochem Company Limited, Vinmar International Ltd., and Mitsubishi Chemical Corporation. The company was formerly known as DNP Green Technology, Inc. and changed its name to BioAmber Inc. in September 2010. BioAmber Inc. is headquartered in Montreal, Canada.
- [By Markus Aarnio]
BioAmber (BIOA) is a sustainable chemicals company. Its proprietary technology platform combines industrial biotechnology and chemical catalysis to convert renewable feedstock into chemicals for use in a wide variety of everyday products including plastics, resins, food additives and personal care products.