Biotech stocksRegeneron Pharmaceuticals (REGN),Biogen (BIIB),Amgen (AMGN) and Celgene (CELG), among themhave staged nice rallies during the past three months but are still down for 2016. Now, Piper Jaffray’s Joshua Schimmer and team ask: “What’s the trade for the rest of the year?” They answer their own question:
Investors are generally lukewarm on biopharma, and many think we’re finally moving towards a ‘stock-pickers’ environment and away from the group trade that has dominated for much of the past year. Some valuations are viewed as more attractive than others, but with few obvious shorts to be found. Much discussion is on M&A target.
Large cap focus: Investors are generally sticking to more liquid names, although we are slowly seeing a return of interest to select small-caps. The general agreement is that fundamentals have changed, biopharma pricing power has eroded, payors/PBMs are wielding considerable power and more uncertainty exists for product outlooks.
Top 5 Japanese Stocks To Buy For 2016: Omeros Corporation(OMER)
Omeros Corporation, incorporated on June 16, 1994, is a biopharmaceutical company. The Company is engaged in discovering, developing and commercializing small-molecule and protein therapeutics for large-market, as well as orphan indications targeting inflammation, coagulopathies and disorders of the central nervous system. Its marketed drug product, Omidria (phenylephrine and ketorolac injection), is launched in the United States for use during cataract surgery or intraocular lens (IOL) replacement. Omidria is derived from the Company’s PharmacoSurgery platform, which is designed for patients undergoing ophthalmological, arthroscopic, urological and other surgical procedures. Its PharmacoSurgery platform is based on low-dose combinations of the United States Food and Drug Administration (FDA) approved therapeutic agents delivered directly to the surgical site throughout the duration of the procedure to inhibit preemptively inflammation and other problems caused by surgical trauma, and to provide clinical assistances both during and after surgery.
The Company’s pipeline includes clinical-stage development programs focused on complement-related thrombotic microangiopathies (TMAs); complement-mediated glomerulopathies; Huntington’s disease and cognitive impairment; addictive and compulsive disorders, and problems associated with urologic surgical procedures. In addition, it has a group of preclinical programs and over two additional platforms: one capable of unlocking new G protein-coupled receptor (GPCR) drug targets and the other used to generate antibodies. OMS103 is the Company’s PharmacoSurgery product candidate, which is developed for use during all arthroscopic procedures, including knee and shoulder arthroscopy, and completed Phase III trials in patients undergoing arthroscopic anterior cruciate ligament reconstruction and arthroscopic partial meniscectomy. OMS103 is a combination of anti-inflammatory/analgesic active pharma ceutical ingredients (APIs), specifically amitriptyline, ket! oprofen and oxymetazoline, and designed to provide a multimodal approach to block preemptively the inflammatory cascade induced by arthroscopy. OMS103 is delivered directly to the joint throughout arthroscopy and is designed to act simultaneously at multiple distinct targets to block preemptively the inflammatory cascade induced by arthroscopic surgery.
Omidria is approved by the FDA for use during cataract surgery or IOL replacement surgery to maintain pupil size by preventing intraoperative miosis (pupil constriction) and to reduce postoperative ocular pain and is approved in all European Union (EU) member states for use during cataract surgery and other IOL replacement procedures to maintain mydriasis (pupil dilation), to prevent miosis and to reduce postoperative eye pain. Omidria is a drug product containing two APIs: ketorolac, an anti-inflammatory agent, and phenylephrine, a mydriatic, or pupil dilating, agent. These procedures are performed to replace a lens opacified by a cataract or to correct a refractive error. Omidria is added to standard irrigation solution used during cataract and lens replacement surgery and is delivered intracamerally, or within the anterior chamber of the eye, to the site of the surgical trauma throughout the procedure.
The Company’s clinical programs include Mannan-binding lectin-associated serine protease-2 (MASP-2) (OMS721)-Lectin Pathway Disorders; PDE10 (OMS824)-CNS Disorders; peroxisome proliferator-activated receptor gamma (OMS405)-Addiction, and OMS201-Urology. The MASP-2 is a pro-inflammatory protein target involved in activation of the complement system. OMS721 is its lead human monoclonal antibody targeting MASP-2. OMS721 has received Orphan Drug designation for the prevention (inhibition) of complement-mediated TMAs, and Fast Track designation for the treatment of patients with Atypical Hemolytic Uremic Syndrome (aHUS). Phosphodiesterase 10 ( PDE10) is an enzyme that is expressed in areas of the brain ! linked to! diseases that affect cognition, including Huntington’s disease and schizophrenia. OMS824 has received Orphan Drug designation for the treatment of Huntington’s disease and Fast Track designation for the treatment of cognitive impairment in patients with Huntington’s disease. OMS824 is in a Phase II clinical program for the treatment of Huntington’s disease and a Phase II clinical program evaluating OMS824 for the treatment of schizophrenia.
The peroxisome proliferator-activated receptor gamma program is developing compositions that include peroxisome proliferator-activated receptor gamma agonists for the treatment and prevention of addiction to substances of abuse, which may include opioids, nicotine and alcohol. It has completed two Phase II clinical trials related to its peroxisome proliferator-activated receptor gamma program. OMS201 is its PharmacoSurgery product candidate designed for use during urological procedures, including ureterscopy for removal of u reteral or renal stones. OMS201 is a combination of ketoprofen, an anti-inflammatory API, and nifedipine, a smooth muscle relaxant API. It has completed a Phase I/Phase II clinical trial.
The Company’s preclinical programs include phosphodiesterase 7 (PDE7) (OMS527), Plasmin (OMS616), MASP-3 (OMS906)-Alternative Pathway Disorders, GPR17-CNS Disorders, GPR101-Metabolic Disorders, GPR151-CNS Disorders, GPR161-Cancer, GPR174-Immune Disorders, GPR183-Skeletal and Infectious Diseases, GPCR Platform and Antibody Platform. The PDE7 program is based on its discoveries of previously unknown links between PDE7 and any addiction or compulsive disorder and between PDE7 and any movement disorders, such as Parkinson’s disease. In its plasmin program, the Company is advancing antifibrinolytic agents for the control of blood loss during surgery or resulting from trauma, as well as for other hyperfibrinolytic states. As part of its MASP program, it has identified MASP-3.
The Company is condu! cting med! icinal chemistry to optimize compounds against GPR17, a GPCR that is linked to myelin formation. It is conducting medicinal chemistry to optimize compounds against GPR101, a GPCR that is linked to appetite and eating disorders. It is conducting medicinal chemistry to optimize compounds against GPR151, a GPCR that is linked to neuropathic pain and cognitive disorders. It is conducting medicinal chemistry to optimize compounds against GPR161, a GPCR that is linked to triple negative breast cancer (TNBC) and sarcomas. It is conducting medicinal chemistry to optimize compounds against GPR174, a GPCR that is linked to autoimmunity. It is conducting medicinal chemistry to optimize compounds against GPR183, a GPCR that is linked to osteoporosis and Epstein-Barr virus (EBV) infections, and associated diseases. The ex vivo platform is for the discovery of monoclonal antibodies, which utilizes a chicken B-cell lymphoma cell line.
The Company competes with The Nordic Group .
- [By Monica Gerson]
Omeros (NASDAQ: OMER) shares fell 2.80% to $8.32 in the pre-market trading. Omeros shares have dropped 9.80% over the past 52 weeks, while the S&P 500 index has gained 16.18% in the same period.
Top 5 Japanese Stocks To Buy For 2016: Manitowoc Company, Inc. (The)(MTW)
The Manitowoc Company, Inc. (MTW), incorporated on July 15, 1920, is a multi-industry, capital goods manufacturer. The Company operates in two principal markets: Cranes and Related Products (Crane) and Foodservice Equipment (Foodservice). Crane is a provider of engineered lifting equipment for the global construction industry, including lattice-boom cranes, tower cranes, mobile telescopic cranes and boom trucks. Foodservice is a manufacturer of commercial foodservice equipment serving the ice, beverage, refrigeration, food-preparation, holding and cooking needs of restaurants, convenience stores, hotels, healthcare and institutional applications. Its Crane products are principally marketed under the Manitowoc, Grove, Potain, National Crane, Shuttlelift and Manitowoc Crane Care brand names. Its Foodservice products, services and solutions are marketed under brands, including Cleveland, Convotherm, Dean, Delfield, Fabristeel, Frymaster, Garland, Inducs, Kolpak, Koolaire, Lin coln, Manitowoc Beverage Systems, Manitowoc Ice, Merco, Merrychef, Moorwood Vulcan, Multiplex, RDI Systems, Servend, TRUpour, U.S. Range and Welbilt, and are supported by Manitowoc KitchenCare.
Cranes and Related Products
The Company’s Crane segment designs, manufactures and distributes a diversified line of crawler-mounted lattice-boom cranes, which the Company sells under the Manitowoc brand name. Its Crane segment also designs and manufactures a diversified line of top-slewing and self-erecting tower cranes, which it sells under the Potain brand name. It designs and manufactures mobile telescopic cranes, which it sells under the Grove and Shuttlelift brand names, and a range of hydraulically powered telescopic boom trucks, which it sells under the National Crane brand name. The Company also provides crane product parts and services, and crane rebuilding, remanufacturing, and training services, which are delivered under the Manitowoc Crane Care br and name. In some cases its products are manufactured for th! e Company or distributed for the Company under strategic alliances. Its crane products are used in a range of applications throughout the world, including energy production/distribution and utilities, petrochemical and industrial projects, and infrastructure applications, such as road, bridge and airport construction, plus commercial and residential construction.
The Company, under the Manitowoc brand name, designs, manufactures and distributes lattice-boom crawler cranes. Lattice-boom cranes consist of a lattice-boom, which is a fabricated steel structure that has approximately four chords and tubular lacings, mounted on a base, which is either crawler or truck mounted. The Company offers models of lattice-boom cranes with lifting capacities of over 2,500 United States tons, which are used to lift material and equipment in a range of applications and end markets, including heavy construction, bridge and highway, duty cycle and infrastructure and energy-related projects. These cranes are also used by the crane rental industry. The Company also offers its lattice-boom crawler crane customers various attachments that provide its cranes with capacity in terms of height, movement and lifting. Its principal attachments are MAX-ER attachments, luffing jibs and RINGER attachments.
The Company, under the Potain brand name, designs and manufactures tower cranes utilized primarily in the energy, building and construction industries. The Company offers a range of tower crane products, including top slewing, luffing jib, topless, self-erecting and special cranes for dams, harbors and other building projects. Top-slewing cranes are the traditional form of tower cranes. Self-erecting cranes are bottom-slewing cranes, which have a counterweight located at the bottom of the mast and are able to be erected, used and dismantled on job sites without assist cranes. Top-slewing tower cranes have a tower and multi-sectioned horizontal jib. It offers over 20 models of top-slewing tower cranes with ma! ximum jib! lengths of over 80 meters and lifting capabilities ranging between 3 and 80 metric tons. Topless tower cranes are a type of top-slewing crane and have no cathead or jib tie-bars on the top of the mast. It offers approximately 20 models of topless tower cranes with maximum jib lengths of over 70 meters and lifting capabilities ranging between 1.1 and 16 metric tons. Luffing jib tower cranes, a type of top-slewing crane, have an angled jib. The Company offers over 10 models of luffing jib tower cranes with maximum jib lengths of over 60 meters and lifting capabilities ranging between 1.6 and 32 metric tons. Self-erecting tower cranes are mounted on axles or transported on a trailer. It offers approximately 20 models of self-erecting cranes with maximum jib lengths of over 50 meters and lifting capacities ranging between 0.65 and 8 metric tons, which are utilized in low to medium rise construction and residential applications.
The Company, under the Grove brand na me, designs and manufactures over 30 models of mobile telescopic cranes utilized primarily in industrial, commercial and construction applications, as well as in maintenance applications to lift and move material at job sites. Mobile telescopic cranes consist of a telescopic boom mounted on a wheeled carrier. The Company offers over four types of mobile telescopic cranes capable of reaching tip heights of over 440 feet with lifting capacities approximately 550 United States tons, which include rough-terrain, all-terrain, truck-mounted and industrial. Rough-terrain cranes are designed to lift materials and equipment on rough or uneven terrain. The Company produces, under the Grove brand name, over 10 models of rough-terrain cranes capable of tip heights of over 310 feet and maximum load capacities of approximately 150 United States tons. All-terrain cranes are cranes designed to lift materials and equipment on rough or uneven terrain. The Company produces, under the Grove bra nd name, over 10 models of all-terrain cranes capable of tip! heights ! of approximately 450 feet and maximum load capacities of over 550 United States tons. It produces, under the Grove brand name, three models of truck mounted cranes capable of tip heights of over 230 feet and maximum load capacities of over 110 United States tons. Industrial cranes are designed for plant maintenance, storage yard and material handling jobs. It manufactures, under the Grove and Shuttlelift brand names, approximately 10 models of industrial cranes. It produces industrial cranes with over 20 United States ton capacity and tip heights of over 80 feet. The Company offers hydraulic boom truck products under the National Crane product line. It offers, under the National Crane brand name, over 20 models of telescoping boom trucks. This type of cranes are capable of reaching maximum heights of over 200 feet and have lifting capacity of over 60 United States tons.
The Company competes with Hitachi Sumitomo, Kobelco, Liebherr, Sumitomo/Link-Belt, Terex, XCM G, Zoomlion, Sany, Comansa, Terex Comedil/Peiner, FM Gru, Jaso, Raimondi, Viccario, Saez, Benezzato, Cattaneo, Yongmao, Wolffkran, Kato, Locatelli, Broderson, Manitex, Altec, Elliott and Tadano.
The Company’s Foodservice Equipment business designs, manufactures and sells primary cooking and warming equipment; ice-cube machines, ice flaker machines and storage bins; refrigerator and freezer equipment; beverage dispensers and related products; serving, warming and storage equipment; and aftermarket parts and service solutions. Its range of products are used by commercial and institutional foodservice operators, such as full service restaurants, quick-service restaurant (QSR) chains, hotels, caterers, supermarkets, convenience stores, business and industry, hospitals, schools and other institutions.
The Company designs, manufactures and sells an array of ranges, griddles, grills, combination ovens, convection ovens, c onveyor ovens, induction cookers, broilers, tilt fry pans/ke! ttles/ski! llets, braising pans, cheese melters/salamanders, cook stations, table top and counter top cooking/frying systems, fryers, steam jacketed kettles and steamers. It sells traditional oven, combi oven, convection oven, conveyor oven, rapid cooking ovens, range and grill products under the Convotherm, Garland, Lincoln, Merrychef, U.S. Range and other brand names. Fryers and frying systems are marketed under the Frymaster and Dean brand names, while steam equipment is manufactured and sold under the Cleveland brand.
The Company designs, manufactures and sells ice machines under the Manitowoc brand name and Koolaire brand names. The Company designs, manufactures and sells commercial upright and undercounter refrigerators and freezers, blast freezers, blast chillers and cook-chill systems under the Delfield brand name. The Company manufactures, under the brand name Kolpak, modular and fully assembled walk-in refrigerators, coolers and freezers, and prefabricated cooler and freezer panels for use in the construction of refrigerated storage rooms and environmental systems. It also designs and manufactures refrigeration systems under the RDI brand name. The Company produces beverage dispensers, blended ice machines, ice/beverage dispensers, beer coolers, post-mix dispensing valves, backroom equipment and support system components and related equipment use by quick-service restaurant chains, convenience stores, bottling operations, movie theaters and the soft-drink industry. Its beverage and related products are sold under the Servend, Multiplex, TRUpour and Manitowoc Beverage Systems brand names. It designs, manufactures and sells a range of cafeteria/buffet equipment stations, bins, boxes, warming cabinets, display and deli cases, insulated and refrigerated salad/food bars, and warmers. Its equipment stations, cases, food bars and food serving lines are marketed under the Delfield and other brand names.
The Company provides par ts and aftermarket service, as well as provides a range of s! olutions ! under the KitchenCare brand name. The end-customer base for the Foodservice segment consists of a range of foodservice providers, including multinational and regional chain restaurants, convenience stores and retail stores; chain and independent casual and family dining restaurants; independent restaurants and caterers; lodging, resort, leisure and convention facilities; healthcare facilities; schools and universities; business and industrial customers, and other foodservice outlets.
The Company competes with Aucma, Brema, Follett, Hoshizaki, Ice-O-Matic, Scotsman, Vogt, Automatic Bar Controls, Celli, Cornelius, Taylor, Vin Service, American Panel, Arctic, Bally, Beverage Air, ICS, Master-Bilt, Nor-Lake, Thermo-Kool, Traulsen, True Foodservice, TurboAir, Ali Group, Dover Industries, Duke, Electrolux, Henny Penny, ITW, Middleby, Rational, Alto Shaam, Cambro, Hatco, Standex and Vollrath.
- [By Ben Levisohn]
With a neutral sector rating, we are working on evaluating risks to negative calls, and identifying potential value opportunities. Last week we noted more work might be worthwhile on Wabco Holdings (WBC), Terex, Manitowoc (MTW), and Caterpillar, two of those names have rallied for other reasons but the attractive price made the upside/downside skew up. We remain positive (OW) on Allison Transmission Holdings (ALSN) & United Rentals. Our and consensus 2017Allison Transmission Holdings estimates have fallen by 2% vs. ~15% for the group, while the shares are down 10% since launch. We continue to see United Rentals as the best value in our group…
Hot Rising Companies For 2016: Nucor Corporation(NUE)
Nucor Corporation, together with its subsidiaries, engages in the manufacture and sale of steel and steel products in North America and internationally. It operates through three segments: Steel Mills, Steel Products, and Raw Materials. The Steel Mills segment produces hot and cold-rolled sheet steel; plate steel; structural steel comprising wide-flange beams, beam blanks, and sheet piling; and bar steel, such as blooms, billets, concrete reinforcing bar, merchant bar, and special bar quality products. The Steel Products segment offers steel joists and joist girders, steel deck, fabricated concrete reinforcing steel, cold finished steel, steel fasteners, metal building systems, light gauge steel framing, steel grating and expanded metal, and wire and wire mesh products. The Raw Materials segment produces direct reduced iron (DRI); brokers ferrous and nonferrous metals, pig iron, hot briquetted iron, and DRI; supplies ferro-alloys; and processes ferrous and nonferrous scrap metal products. The company?s operations also include various international trading companies that buy and sell steel and steel products. It sells its hot-rolled steel and cold-rolled steel to steel service centers, fabricators, and manufacturers; steel joists and joist girders, and steel deck to general contractors and fabricators; and cold finished steel and steel fasteners to distributors and manufacturers. The company?s products are used by contractors in constructing highways, bridges, reservoirs, utilities, hospitals, schools, airports, stadiums, and high-rise buildings. Nucor Corporation was founded in 1940 and is based in Charlotte, North Carolina.
- [By Wayne Duggan]
JPMorgan names United States Steel Corporation (NYSE: X), AK Steel Holding Corporation (NYSE: AKS), Steel Dynamics, Inc. (NASDAQ: STLD) and Nucor Corporation (NYSE: NUE) as its top steel stock picks.
- [By Ben Levisohn]
Given revised commodity deck forecasts (particularly for Steel and Gold) and improved Balance Sheet health (Steels, Precious and Industrials Metals) we are upgrading our ratings on several stocks in our coverage. We generally favor companies that have already initiated specific self-help, have low-cost assets and are less exposed to China supply and demand dynamics. In Steels, we have increased our rating from Hold to Buy on Nucor (NUE) and from Sell to Hold on US Steel. We have also upgraded Kinross Gold (KGC) to a Hold on valuation…On higher-than-peer valuations, we reiterate Sell-rated Coeur Mining (CDE), Franco-Nevada (FNV), Goldcorp (GG), Teck Resources (TCK) and highly leveraged AK Steel given preference to issue further equity if possible.
Top 5 Japanese Stocks To Buy For 2016: Investment Technology Group, Inc.(ITG)
Investment Technology Group, Inc. operates as an independent broker and financial technology company in the United States, Canada, Europe, and the Asia Pacific. The company offers electronic brokerage; research, sales, and trading; platforms; and analytics solutions for asset managers and broker-dealers. It provides trade execution services and solutions for portfolio management, as well as investment research, pre-trade analytics, and post-trade analytics and processing. The company offers ITG Algorithms and ITG Smart Router that offers portfolio managers and traders to trade orders; POSIT for continuous and scheduled crossing of non-displayed equity orders and price improvement opportunities; ITG Derivatives for electronic listed futures and options trading; ITG Commission Manager, a Web-based commission management portal; and securities lending services. It also offers Execution Management System, which provides multi-asset trading opportunities; Order Management System that combines portfolio management, compliance functionality, and a financial services communications network; ITG Position Manager, a broker-neutral order management system; ITG Net, a financial communications network; ITG RFQ-hub, a platform for global-listed and over-the-counter financial instruments; and ITG Single Ticket Clearing, a broker-neutral operational service. In addition, the company offers ITG Trading Analytics, which enhances execution performance before the trade happens and during trading by providing reliable trading analytics and risk models; and ITG Portfolio Analytics that assists asset managers with portfolio decision-making tasks from portfolio construction and optimization. Further, it offers institutional broker-dealer services; data-driven investment research; and trade order and execution management technology and network connectivity services for the financial community. Investment Technology Group, Inc. was founded in 1983 and is headquartered in New York, ! New York.
- [By Jon C. Ogg]
Investment Technology Group Inc. (NYSE: ITG) was downgraded to Market Perform from outperform by KeefeBruyette & Woods.
Liquidity Services Inc. (NASDAQ: LQDT) was raised to Buy from Underperform, and the price target was raised up to $45 from $28.50, at Merrill Lynch.
Top 5 Japanese Stocks To Buy For 2016: Nordstrom Inc.(JWN)
Nordstrom, Inc., a fashion specialty retailer, offers apparel, shoes, cosmetics, and accessories for women, men, and children in the United States. It offers a selection of brand name and private label merchandise. The company sells its products through various channels, including Nordstrom full-line stores, off-price Nordstrom Rack stores, Jeffrey? boutiques, treasure & bond, and Last Chance clearance stores; and its online store, nordstrom.com, as well as through catalog. Nordstrom also provides a private label card, two Nordstrom VISA credit cards, and a debit card for Nordstrom purchases. The company?s credit and debit cards feature a shopping-based loyalty program. As of September 30, 2011, it operated 222 stores, including 117 full-line stores, 101 Nordstrom Racks, 2 Jeffrey boutiques, 1 treasure & bond store, and 1 clearance store in 30 states. The company was founded in 1901 and is based in Seattle, Washington.
- [By Lisa Levin]
Nordstrom, Inc. (NYSE: JWN) was down, falling around 7 percent to $49.15 after the company reported weaker-than-expected results for its fourth quarter on Thursday.