For many, stocks listed on the “Pink Sheets” are to be avoided, as it regarded as the province of thinly-traded, poorly capitalized firms that could not qualify to be listed on “The Big Board” or other, more reputable exchanges.
While that sadly can be the case, there are many blue chips listed on the PInk Sheets that compare with the finest on The New York Stock Exchange or NASDAQ.
One example is Swisscom (OTC: SCMWY), a $26 billion major communications conglomerate operating from Switzerland that compares favorably with AT&T (NYSE: T), Verizon (NYSE: VZ) and Frontier Communications (NASDAQ: FTR).
Hot Trucking Companies To Own In Right Now: Costamare Inc (CMRE)
Costamare Inc. (Costamare), incorporated on April 21, 2008, is an international owner of containerships, chartering the Company’s vessels to liner companies. As of February 22, 2013, it had a fleet of 57 containerships aggregating approximately 332,000 twenty feet equivalent unit (TEU). During the year ended December 31, 2012, its fleet consisted of 47 vessels in the water, aggregating approximately 242,000 TEU. The Company’s containerships operate primarily under multi-year time charters.
As of February 22, 2013, the average (weighted by TEU capacity) remaining time-charter duration for its fleet of 57 containerships was 5.1 years. During the year ended December 31, 2012, the Company’s vessels were managed by at least one of Costamare Shipping, CIEL and Shanghai Costamare. The Company’s customers include international liner companies, including A.P. Moller-Maersk, COSCO, Evergreen Marine, Hapag Lloyd, HMM, MSC and ZIM.
- [By Rich Duprey]
Containership owner and provider Costamare (NYSE: CMRE ) announced yesterday its second-quarter dividend of $0.27 per share, the same rate it’s paid since late 2011.
- [By Seth Jayson]
Costamare (NYSE: CMRE ) reported earnings on July 24. Here are the numbers you need to know.
The 10-second takeaway
For the quarter ended June 30 (Q2), Costamare missed estimates on revenues and beat expectations on earnings per share.
Hot Trucking Companies To Own In Right Now: Qualys Inc (QLYS)
Qualys, Inc. (Qualys), incorporated on December 30, 1999, is a provider of clouds security and compliance solutions that enable organizations to identify security risks to their information technology (IT) infrastructures, help protect their IT systems and applications from cyber attacks and achieve compliance with internal policies and external regulations. The Company designed its QualysGuard Cloud Platform to transform the way organizations secure and protect their IT infrastructures and applications The Company’s cloud platform offers an integrated suite of solutions that automates the lifecycle of asset discovery, security assessments, and compliance management for an organization’s IT infrastructure and assets, whether they reside inside the organization, on their network perimeter or in the cloud.
The Company provides its solutions through a software-as-a-service model, primarily with renewable annual subscriptions. These subscriptions require custome rs to pay a fee in order to access the Company’s cloud solutions. The Company’s QualysGuard Cloud Platform consists of a suite of IT security and compliance solutions that leverage the Company’s shared and extensible core services and its scalable multi-tenant cloud infrastructure. The Company’s suite of solutions provides security intelligence by automating the life cycle of IT asset discovery, security assessment and compliance management. The Company’s cloud platform’s infrastructure includes integrated services that deliver a automated and scalable scanning infrastructure capable of scanning IT systems and Web applications, inside and outside corporate firewalls. The Company also provides open application program interfaces (APIs), and other developer tools that allow third parties to embed its technology into their solutions and build applications on its cloud platform.
The Company’s suite of solutions, which the Company refers to as the QualysGuard Cloud S uite, includes Vulnerability Management, Web Application Sca! nning, Malware Detection Service, Policy Compliance, PCI Compliance and Qualys SECURE Seal. The Company’s customers can subscribe to one or more of the Company’s security and compliance solutions based on their initial needs and expand their subscriptions over time to new areas within their organization or to additional QualysGuard solutions. The Company offers two editions of its QualysGuard Cloud Suite, the Enterprise edition for large and medium-sized enterprises and the Express edition for small and medium-sized businesses.
QualysGuard Vulnerability Management (QualysGuard VM), is a solution that automates network auditing and vulnerability management across an organization, including network discovery and mapping, asset management, vulnerability reporting, and remediation tracking. QualysGuard Policy Compliance (QualysGuard PC) allows customers to analyze and collect configuration and access control information from their networked devices and Web applicati ons and automatically maps this information to internal policies and external regulations in order to document compliance.
QualysGuard PCI Compliance (QualysGuard PCI) provides organizations that store cardholder data a automated solution to verify and document compliance with PCI DSS. QualysGuard Web Application Scanning (QualysGuard WAS) uses the scalability of its cloud platform to allow customers to discover, catalog and scan a large number of Web applications. QualysGuard Malware Detection Service (QualysGuard MDS) provides organizations with the ability to scan identify and remove malware infections from their Websites. QualysGuard Web Application Firewall (QualysGuard WAF) delivers enterprise-grade Web application security without associated with appliance-based Web application firewall solutions. QualysGuard SECURE Seal helps organizations demonstrate to their online customers that they maintain a proactive security program.
Core Services in clude asset tagging and management, reporting and dashboards! , questio! nnaires and collaboration, remediation and workflow, big data correlation and analytics engine, and alerts and notifications. The Company’s infrastructure layer, which it refer to as its Infrastructure, includes the data, data processing capabilities, software and hardware infrastructure and infrastructure management capabilities that provide the foundation for its cloud platform and allow the Company to automatically scale its Infrastructure and Core Services to scan millions of Internet protocols (IPs).
The Company competes with Hewlett-Packard Company, Imperva, Inc., International Business Machines Corporation, McAfee, Inc., Symantec Corporation, Barracuda Networks, Inc., BeyondTrust Software, Inc., Lumension Security, Inc., nCircle Network Security, Inc., NetIQ Corporation, Rapid7 LLC, Tenable Network Security, Inc. and Trustwave Holdings, Inc.
- [By Jake L’Ecuyer]
Equities Trading UP
Qualys (NASDAQ: QLYS) shares shot up 10.23 percent to $21.07 after the company reported upbeat quarterly results.
Shares of Office Depot (NYSE: ODP) got a boost, shooting up 15.95 percent to $4.84 after the company reported upbeat quarterly earnings and announced its plans to close at least 400 stores in the US.
- [By Jake L’Ecuyer]
Equities Trading UP
Qualys (NASDAQ: QLYS) shares shot up 8.24 percent to $20.68 after the company reported upbeat quarterly results.
Shares of Office Depot (NYSE: ODP) got a boost, shooting up 15.95 percent to $4.84 after the company reported upbeat quarterly earnings and announced its plans to close at least 400 stores in the US.
Hot Trucking Companies To Own In Right Now: Performant Financial Corp (PFMT)
Performant Financial Corporation (Performant), incorporated on October 8, 2003, provide technology-enabled recovery and related analytics services in the United States. The Company’s services help identify and recover delinquent or defaulted assets and improper payments for both government and private clients in a broad range of markets. The Company provides its services on an outsourced basis, where the Company handles many or all aspects of its clients’ recovery processes. The Company derives its revenues from services for clients in a range of different markets. These markets include student lending and healthcare, as well as its other markets, which include delinquent state taxes and federal Treasury and other receivables. The Company’s clients include 12 of the 32 public sector participants in the student loan industry. In February 2012, it purchased a perpetual software license and computer equipment from HOPS, Inc.
Th e Company derives its revenues from the recovery of student loans. These revenues are contract-based and consist primarily of contingency fees based on a specified percentage of the amount the Company enables its clients to recover. The Company engages subcontractors to assist in the recovery of a portion of the client’s portfolio. It also receives success fees for the recovery of loans under Master Service Agreements (MSAs) and its revenues under MSA arrangements include fees earned by the activities of its subcontractors. The Company uses its technology to identify, track and communicate with defaulted borrowers on behalf of its clients to implement suitable recovery programs for the repayment of outstanding student loan balances.
The Company’s client’s contract with it to provide recovery services for large pools of student loans generally representing a portion of the total outstanding defaulted balances they manage, which they provide to us as placeme nts on a periodic basis. The Company also restructures and r! ecovers student loans issued directly by banks to students outside of federal lending programs.
The Company derives revenues from the healthcare market primarily from its Recovery Audit Contractor (RAC), contract, under, which it is a prime contractor responsible for detecting improperly paid Part A and Part B Medicare claims in 12 states in the Northeastern United States. Revenues earned under the RAC contract are driven by the identification of improperly paid Medicare claims through both automated and manual review of such claims. The Company outsourced certain aspects of its healthcare recovery process to three different subcontractors.
The Company derives revenues from the recovery of delinquent state taxes, and federal Treasury and other receivables, default aversion services for certain clients, including financial institutions and the licensing of hosted technology solutions to certain clients. F or its hosted technology services, the Company licenses its system and integrates its technology into its clients’ operations, for which it is paid a licensing fee. The Company’s revenues for these services include contingency fees, fees based on dedicated headcount to its clients and hosted technology licensing fees. The federal agency market consists of government debt subrogated to the Department of the Treasury.
For state and municipal tax authorities, the Company analyzes a portfolio of delinquent tax and other receivables placed with the Company, develop a recovery plan and execute a recovery process designed to maximize the recovery of funds. In some instances, it has also run state tax amnesty programs, which provide one-time relief for delinquent tax obligations, and other debtor management services for its clients. For the Department of the Treasury, it recovers government debt subrogated to it by numerous different federal agencies. The placements it has provided represent a mix of commercial and individual oblig! ations.
Data Management Expertise
The Company’s platform manages and stores large amounts of data throughout the workflow process. This includes both data it has compiled, as well as third-party data.
Data Analytics Capabilities
The Company’s data analytics capabilities screen and allocate massive volumes of recovery inventory. Upon receipt of each placement of student loans, the Company utilize its algorithms to assist its in determining the recovery process and the optimal allocation of recovery specialist resources for each loan. In the healthcare market, the Company analyze millions of Medicare claims to find potential correlations between claims data and improper payments.
The Company refers to the patented technology that supports its workflows as Smart Bins. The Company’s workflow processes integrate a range of functions that encompass each stage of a recovery process.
The Company competes with Health Management Systems, Inc., Connolly Consulting, Inc. and CGI Group.
- [By Magic Diligence]
Much of United Online’s appeal was due to its over 4% dividend yield, but the company announced in late January that it would be discontinuing its dividend to focus on growth initiatives. This follows itsNovember spin-off of FTD, which leaves United with 3 cash producing but declining businesses: Classmates.com, NetZero, and Juno. NetZero Mobile Broadband is an interesting product but one with a lot of competition from the carriers. Frankly, the dividend has been the main attraction for some time, and without it this is a declining company with a fair bit of debt. That does not make for the most attractive option. PASS.
Performant Financial (PFMT) – down 28.1%
Performant earns fees for collecting delinquent student loans (about 60% of the business) and providing recovery services for improper Medicare payments (close to 30%). The recent sell-off in the stock seems due to comments from Sallie Mae regarding lower rehabilitation fees paid to Guarantee Agencies, which investors expect to “trickle down” to service providers like PFMT. The stock has been sold off dramatically on these assumptions. We should know more when the company reports earnings in the coming weeks, but this is one worth looking at more closely – the firm has been growing revenue at 30%+ rates. WORTHY OF CONSIDERATION.
- [By Roberto Pedone]
Performant Financial (PFMT) provides technology-enabled recovery and related analytics services in the U.S. This stock closed up 6.9% at $11.84 in Friday’s trading session.
Friday’s Volume: 310,000
Three-Month Average Volume: 261,916
Volume % Change: 60%
From a technical perspective, PFMT soared higher here right off both its 200-day moving average of $11.02 and its 50-day moving average at $11.06 with decent upside volume. This move is quickly pushing shares of PFMT within range of triggering a major breakout trade. That trade will hit if PFMT manages to take out some near-term overhead resistance levels at $12.47 to $13.26 with high volume.
Traders should now look for long-biased trades in PFMT as long as it’s trending above its 200-day at $11.02 and then once it sustains a move or close above those breakout levels with volume that’s near or above 261,916 shares. If that breakout hits soon, then PFMT will set up to re-test or possibly take out its all-time high at $14.09. Any high-volume move above $14.09 will then give PFMT a chance to trend north of $15.
Hot Trucking Companies To Own In Right Now: Powershares Dynamic Media Portfolio (PBS)
PowerShares Dynamic Media Portfolio (the Fund) seeks investment results that correspond generally to the price and yield of an equity index called the Dynamic Media Intellidex Index (the Media Intellidex). The Media Intellidex consists of stocks of 30 United States media companies. These are companies that are principally engaged in the development, production, sale and distribution of goods or services used in the media industry. These companies may include advertising, marketing and public relations companies; companies that own, operate or broadcast free or pay television, radio or cable stations; theaters; film studios; publishers or sellers of newspapers, magazines, books or video products; printing, cable television and video companies and equipment providers; pay-per-view television companies; companies involved in emerging technologies for the broadcast and media industries; cellular communications companies; companies involved in the development, syndication and t ransmission of television, movie programming, advertising and cellular communications; companies that distribute data-based information, and other companies involved in the ownership, operation or development of media products or services. Stocks are selected principally on the basis of their capital appreciation potential as identified by the AMEX (the Intellidex Provider) pursuant to its Intellidex methodology.
The Fund will normally invest at least 80% of its total assets in common stocks of media companies. The Fund will normally invest at least 90% of its total assets in common stocks that comprise the Media Intellidex. The Media Intellidex is adjusted quarterly, and the Fund, using an indexing investment approach, attempts to replicate the performance of the Media Intellidex. The Fund’s investment advisor is PowerShares Capital Management LLC.
- [By John Udovich]
On Monday, shares of small cap Rocket Fuel Inc (NASDAQ: FUEL) took off like a rocket by surging 18.96% after plunging about 20% on Friday after earnings – meaning it might be time to take a closer look at the stock as well as benchmark it with the performance of the Global X Social Media Index ETF (NASDAQ: SOCL) and the PowerShares Dynamic Media Portfolio ETF (NYSEARCA: PBS).
- [By John Udovich]
Small cap media stock LIN Media LLC (NYSE: LIN) might not be a household name, but there is a good chance you might be watching the company’s programs because like the Sinclair Broadcast Group, Inc (NASDAQ: SBGI) and Nexstar Broadcasting Group, Inc (NASDAQ: NXST), its helping to consolidate the media industry plus its making investment in other forms of media like social media. The stock has also outperformed those two peers along with the PowerShares Dynamic Media Portfolio ETF (NYSEARCA: PBS).
Hot Trucking Companies To Own In Right Now: Australia and New Zealand Banking Group Ltd (ANZ)
Australia and New Zealand Banking Group Limited (ANZ) provides a range of banking and financial products and services to retail, small business, corporate and institutional clients. The Company conducts its operations in Australia, New Zealand and the Asia Pacific region. It also operates in a range of other countries, including the United Kingdom and the United States. The Company operates on a divisional structure with Australia, International and Institutional Banking (IIB), New Zealand, and Global Wealth and Private Banking. As of September 30, 2012, the Company had 1,337 branches and other points of representation worldwide, excluding automatic teller machines (ATMs). In September 2012, it sold its remaining shareholding in Visa Inc. Advisors’ Opinion:
- [By Adam Haigh]
Komatsu Ltd. tumbled 8 percent in Tokyo after the world’s second-largest maker of construction equipment cut its full-year profit forecast by 26 percent. Industrial & Commercial Bank of China Ltd. gained 1.4 percent in Hong Kong, pacing an advance among Chinese lenders, after China’s central bank added funds to the financial system for the first time in two weeks. Australia & New Zealand Banking Group Ltd. (ANZ) climbed 1.4 percent to a record in Sydney after posting its highest profit and raising its dividend more than forecast.
- [By Adam Haigh]
Australia & New Zealand Banking Group Ltd. (ANZ) sank 3 percent after Australia’s third-largest bank by market value forecast interest margins will keep dropping. Hyundai Merchant Marine Co. jumped 6.9 percent in Seoul after North Korea and South Korea agreed to reopen the Gaeseong industrial complex. Chinese stock exchange officials are investigating a spike in the Shanghai Composite Index, which soared from a loss of as much as 1 percent to a gain of 5.6 percent in two minutes. Everbright Securities Co. said it experienced a trading error.
- [By Weiyi Lim]
The funds lured a net $25.9 billion in the period, Wei Liang Chang, a foreign-exchange strategist at Australia & New Zealand Banking Group Ltd. (ANZ), said by phone from Singapore today, citing data from EPFR Global. Developed markets posted $24.3 billion of inflows, while emerging-nation funds drew $1.6 billion, according to Chang.
Hot Trucking Companies To Own In Right Now: AspenBio Pharma Inc.(APPY)
AspenBio Pharma, Inc. operates as an emerging biomedical company focused on obtaining the United States FDA clearance for its lead product, AppyScore. Its research and development activities primarily focus on a human appendicitis blood-based test. The company?s lead product candidate, AppyScore, is a blood-based diagnostic test to help physicians manage patients who enter emergency rooms complaining of abdominal pain and suspected of having acute appendicitis. It is also developing animal healthcare products focusing on reproduction. The company was formerly known as AspenBio, Inc. and changed its name to AspenBio Pharma, Inc. on September 26, 2005. AspenBio Pharma, Inc. was founded in 2000 and is based in Castle Rock, Colorado.
- [By Wallace Witkowski]
Venaxis Inc. (APPY) shares fell 12% to $2.38 on light volume after the medical diagnostics company said it planned to launch an secondary offering of an unspecified number of shares.
- [By Monica Gerson]
Venaxis (NASDAQ: APPY) soared 22.83% to $3.33 in the pre-market trading on positive top-line results from pivotal study of APPY1 test.
Plug Power (NASDAQ: PLUG) shares gained 11.18% to $7.56 in the pre-market after the company reported fourth-quarter results. Plug Power posted a quarterly loss of $0.08 per share, versus the estimated loss of $0.08 per share.
- [By Bryan Murphy]
If you’re reading this, then odds are you know that Venaxis Inc. (NASDAQ:APPY) shares are up a solid 10% today, while the market as a whole is in the red. What you may not know about APPY, however, is that with today’s strength, the stock has worked its way past a big hurdle and put itself into a situation where more upside is very likely.
Hot Trucking Companies To Own In Right Now: Enertopia Corp (ENRT)
Enertopia Corp (Enertopia), incorporated on November 24, 2004, is engaged in medicinal marijuana business. The Company is diverse in its pursuit of business opportunities in several sectors, including: Medicinal Marijuana, Oil and Gas, Solar PV (Photovoltaic), Solar Thermal (Hot Water), Energy Retrofits and Recovery, and Solar powered Filtered Drinking Water.
The Company no longer has any material oil and gas resources. The Company operates in two segments: renewable energy, and mining exploration and developments, which are managed separately based on fundamental differences in their operations nature.
- [By Peter Graham]
What’s the Catch With Lexaria Corp? According to various disclosures, a transaction or transactions of $1k has or will occur to mention Lexaria Corp in various investment newsletters. Last Friday, Lexaria Corp announced it had closed its Private Placement financing announced on March 5 for gross proceeds of $1,272,000 – higher than the originally announced $960,000 figure due to “overwhelming demand.” Lexaria Corp will issue 10,600,000 common shares at US$0.12 and 10,600,000 full warrants that expire on September 21, 2016 with an exercise price of US$0.25. However, the company may also accelerate the expiry date of the warrants if the stock price trades above CAD$0.40 cents for 20 consecutive days at any time after 6 months and one day has elapsed. Otherwise and in early March, Lexaria Corp reported that its board of directors had decided to make a strategic entry into the medical marijuana business by way of an “important Joint Venture” with Enertop ia Corp (OTCQB: ENRT). Under the terms of the Agreement, Lexaria Corp had agreed to pay Enertopia 1 million restricted common shares in return for Enertopia’s participation plus 500,000 restricted common shares ENRT’s Chairman in return for his participation on the Lexaria Advisory Board. Following the issuance of these shares, Lexaria Corp will have a total of 18,431,452 shares issued and outstanding and 21,256,452 shares fully diluted. A quick look at Lexaria Corp’s financials reveals revenues of $160k (most recent reported quarter), $241k, $251k and $253k for the past four quarters along with net losses of $102k (most recent reported quarter), $126k, $58k and $48k. At the end of last January, Lexaria Corp had $66k in cash to cover $1,415k in current liabilities and $59k in other liabilities. So aside from the income statement, investors might want to look more closely at Lexaria Corp’s financing terms.
Hot Trucking Companies To Own In Right Now: CSG Systems International Inc.(CSGS)
CSG Systems International, Inc. provides business support solutions primarily to the communications industry. Its suite of solutions comprises Advanced Convergent Platform, a billing and customer care, and business optimization platform; Singleview suite, an integrated customer care, billing, and real-time rating and charging solution; Total Service Mediation (TSM) framework supports offline, and real-time mediation requirements, as well as service activation; and Wholesale Business Management (WBM) solution, a wholesale settlement and routing solution that handles various types of traffic consisting of voice, data, and content. The company?s solutions also include customer interaction management solutions that deliver interactive voice, SMS/text, print, email, Web, and fax messages on behalf of clients; analytics and intelligence services suite delivers an approach for enhancing the customer experience, increasing sales opportunities, and optimizing business; and Content Direct solutions, which enable content providers to manage subscriber preferences and offer digital content. It also licenses software products, such as WBM solution, TSM, and Singleview products; and offers professional services to implement these software products. The company also provides its services to financial services, healthcare, utilities, entertainment, and content distribution industries. It operates in the Americas, Europe, the Middle East, Africa, and the Asia Pacific. The company was founded in 1994 and is headquartered in Englewood, Colorado.
- [By Seth Jayson]
Calling all cash flows
When you are trying to buy the market’s best stocks, it’s worth checking up on your companies’ free cash flow once a quarter or so, to see whether it bears any relationship to the net income in the headlines. That’s what we do with this series. Today, we’re checking in on CSG Systems International (Nasdaq: CSGS ) , whose recent revenue and earnings are plotted below.
- [By Rich Duprey]
Telecom industry services provider CSG Systems (NASDAQ: CSGS ) announced today that it would initiate the payment of a quarterly dividend to investors, marking the first time in company history it has done so.
Hot Trucking Companies To Own In Right Now: Galena Biopharma Inc (GALE)
Galena Biopharma, Inc. (Galena), formerly RXi Pharmaceuticals Corporation, incorporated on April 3, 2006, is a biotechnology company focused on discovering, developing and commercializing therapies addressing unmet medical needs using targeted biotherapeutics. The Company is pursuing the development of cancer therapeutics using peptide-based immunotherapy products, including its main product candidate, NeuVaxTM (E75), for the treatment of breast cancer and other tumors. NeuVax is a peptide-based immunotherapy intended to reduce the recurrence of breast cancer in low-to-intermediate HER2-positive breast cancer patients not eligible for trastuzumab (Herceptin; Genentech/Roche). On January 19, 2012, the Company initiated enrollment in its Phase 3 PRESENT clinical trial for NeuVax (E75 peptide plus GM-CSF) vaccine in low-to-intermediate HER2 1+ and 2+ breast cancer patients in the adjuvant setting to prevent recurrence (Clinicaltrials.gov identifier NCT01479244). The Preventio n of Recurrence in Early-Stage, Node-Positive Breast Cancer with Low to Intermediate HER2 Expression with NeuVax Treatment study is a randomized, multicenter, multinational clinical trial that will enroll approximately 700 breast cancer patients. The Company’s Phase 2 trial of NeuVax achieved its primary endpoint of disease-free survival (DFS). On April 13, 2011, the Company completed its acquisition of Apthera, Inc.,(Apthera).
The Company focuses to start a Phase 2 trial comparing NeuVax in combination with trastuzumab (Herceptin) versus trastuzumab, alone, in a 300-patient, randomized study in the adjuvant breast cancer setting. The Company’s second product candidate, Folate Binding Protein-E39 (FBP), is a vaccine, consisting of the peptides E39 and J65, aimed at preventing the recurrence of ovarian, endometrial, and breast cancers. On February 14, 2012, the Company announced the initiation of a Phase 1/2 clinical trial in two gynecological cancers: ovarian and endometrial adenocarcinomas. Folate binding protein has ! very limited tissue distribution and expression in non-malignant tissue and is over-expressed in more than 90% of ovarian and endometrial cancers, as well as in 20% to 50% of breast, lung, colorectal and renal cell carcinomas.
In April 2011, the Company acquired Apthera Inc and its NeuVax product candidate. The Company focuses on developing a pipeline of immunotherapy product candidates for the treatment of various cancers based on the E75 peptide, the advanced of which is NeuVax, which is targeted at preventing the recurrence of breast cancer. NeuVax has had positive Phase 1/2 clinical trial results for the prevention of breast cancer recurrence in patients who have had breast cancer and received the standard of care treatment (surgery, chemotherapy, radiotherapy and hormonal therapy as indicated). The Company had also initiated its Phase 3 PRESENT clinical trial of NeuVax for the prevention of breast cancer recurrence in early-stage low-to-intermediate HER2 br east cancer patients. NeuVax directs killer T-cells to target and destroy cancer cells that express HER2/neu, a protein associated with epithelial tumors in breast, ovarian, pancreatic, colon, bladder and prostate cancers. NeuVax is comprised of a HER2/neu-derived peptide called E75. E75 is a nine-amino acid sequence that is immunogenic (produces an immune response) and GM-CSF is a commercially available protein that acts to stimulate and activate components of the immune system such as macrophages and dendritic cells.
The Company also develops novel applications for NeuVax based on preclinical studies and phases 2 clinical trials which suggest that combining NeuVax and trastuzumab (Herceptin; Genentech/Roche) can increase antigen presentation by tumor cells by promoting receptor internalization and subsequent proteosomal degradation of the HER2 protein. The Company also is pursuing additional therapeutic indications for NeuVax that are in Phase 1/2 clinical tri als. RXI-109, is a dermal anti-scarring therapy that targets! connecti! ve tissue growth factor (CTGF) and that may inhibit connective tissue formation in human fibrotic disease.
The Company competes with Roche Laboratories, Inc., Pfizer Inc., Bayer HealthCare AG, Sanofi-Aventis, US, LLC, Amgen, Inc., GlaxoSmithKline plc, Renovo Group plc, CoDa Therapeutics, Inc., Sirnaomics, Inc., FirstString Research, Inc., Merz Pharmaceuticals, LLC, Capstone Therapeutics, Halscion, Inc., Garnet Bio Therapeutics, Inc., AkPharma Inc., Promedior, Inc., Kissei Pharmaceutical Co., Ltd., Eyegene, Derma Sciences, Inc., Healthpoint Biotherapeutics, Pharmaxon, Excaliard Pharmaceuticals, Inc., Alnylam Pharmaceuticals, Inc., Marina Biotech, Inc., Tacere Therapeutics, Inc., Benitec Limited, OPKO Health, Inc., Silence Therapeutics plc, Quark Pharmaceuticals, Inc., Rosetta Genomics Ltd., Lorus Therapeutics, Inc., Tekmira Pharmaceuticals Corporation, Arrowhead Research Corporation, Regulus Therapeutics Inc. and Santaris.
- [By James E. Brumley]
The last two weeks have been absolutely fantastic ones for Galena Biopharma Inc. (NASDAQ:GALE). Shares have soared from $2.37 to the current price of $3.32 – a 40% pop – rewarding investors who had been patiently waiting through late October for the runup to take hold. Congratulations if that’s you. But, if that was you, then now might be a great time to take the money and run with the trade, as GALE looks poised to make a sizeable pullback. More on that in a moment.
- [By James E. Brumley]
It may look like little more than a choppy mess with just a quick glance at Galena Biopharma Inc. (NASDAQ:GALE). But, the more you study the chart – and the company – the more you realize there’s enough long-term potential from the company’s pipeline to keep spurring GALE in a generally-upward direction. In fact, the bulls look like they’re on the verge of taking Galena Biopharma out of second gear and putting it into third. As such, it may not be a bad bet at this point.
- [By Sean Williams]
The waiting game
The tables are clearly stacked against small biotech companies developing cancer drugs. History has shown that few (if any) have successfully had the Food and Drug Administration approve a late-stage cancer drug. While mid-stage trials of Galena Biopharma’s (NASDAQ: GALE ) HER2-targeting breast cancer vaccine have been promising thus far, the chances of an approval seem a long way off.